In Vivo Carbon-13 Dynamic MRS and MRSI of Normal and Fasted Rat Liver with Hyperpolarized 13C-Pyruvate

@inproceedings{Hu2009InVC,
  title={In Vivo Carbon-13 Dynamic MRS and MRSI of Normal and Fasted Rat Liver with Hyperpolarized 13C-Pyruvate},
  author={Simon Hu and Albert Y. P. Chen and Matthew L. Zierhut and Robert A Bok and Yeen Peng Yen and Marie A. Schroeder and Ralph E. Hurd and Sarah J. Nelson and John Kurhanewicz and Daniel B. Vigneron},
  booktitle={Molecular Imaging and Biology},
  year={2009}
}
The use of in vivo 13C nuclear magnetic resonance spectroscopy in probing metabolic pathways to study normal metabolism and characterize disease physiology has been limited by its low sensitivity. However, recent technological advances have enabled greater than 50,000-fold enhancement of liquid-state polarization of metabolically active 13C substrates, allowing for rapid assessment of 13C metabolism in vivo. The present study applied hyperpolarized 13C magnetic resonance spectroscopy to the… CONTINUE READING
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