In Vivo CD8+ T-Cell Suppression of SIV Viremia Is Not Mediated by CTL Clearance of Productively Infected Cells

@inproceedings{Wong2010InVC,
  title={In Vivo CD8+ T-Cell Suppression of SIV Viremia Is Not Mediated by CTL Clearance of Productively Infected Cells},
  author={Joseph K Wong and Matthew C. Strain and Rodin Porrata and Elizabeth Reay and Sumathi Sankaran-Walters and Caroline C. Ignacio and Theresa A Russell and Satish Pillai and David J. Looney and Satya Dandekar},
  booktitle={PLoS pathogens},
  year={2010}
}
The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and adaptive mechanisms. We studied viral dynamics during antiretroviral treatment of simian immunodeficiency virus (SIV) infected rhesus macaques following CD8+ T-cell depletion to test the importance of adaptive cytotoxic effects in clearance of cells productively infected with SIV. As previously described, plasma viral load (VL) increased… CONTINUE READING