In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.

Abstract

The in vivo biotransformation of a novel fusion protein tetranectin/apolipoprotein A1 (TN-ApoA1) was investigated by ligand-binding mass spectrometry (LB-MS) in support of enzyme-linked immunosorbent assays (ELISA). The main focus was on catabolites formed by proteolysis of the fusion protein in rabbit following intravenous administration of lipidated TN… (More)

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@article{Zell2016InVB, title={In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.}, author={Manfred Zell and Christophe Husser and Roland F. Staack and Gregor Jordan and Wolfgang Richter and Simone Schadt and Axel Paehler}, journal={Analytical chemistry}, year={2016}, volume={88 23}, pages={11670-11677} }