In Vivo Activity of Norhydrocodone: An Active Metabolite of Hydrocodone

@article{Navani2013InVA,
  title={In Vivo Activity of Norhydrocodone: An Active Metabolite of Hydrocodone},
  author={Dipesh M. Navani and B. Yoburn},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2013},
  volume={347},
  pages={497 - 505}
}
  • Dipesh M. Navani, B. Yoburn
  • Published 2013
  • Medicine
  • The Journal of Pharmacology and Experimental Therapeutics
  • Hydrocodone is primarily metabolized to hydromorphone and norhydrocodone. Although hydromorphone is a known active metabolite of hydrocodone, the in vivo activity of norhydrocodone is not well documented. In the current study, the pharmacodynamics of norhydrocodone were evaluated and compared with hydrocodone and hydromorphone. Binding studies established that norhydrocodone, similar to hydrocodone and hydromorphone, is a μ-selective opioid ligand. In vivo analgesia studies (tail flick… CONTINUE READING
    19 Citations

    Figures, Tables, and Topics from this paper

    Ethanol Reversal of Tolerance to the Antinociceptive Effects of Oxycodone and Hydrocodone
    • 13
    • Highly Influenced
    • PDF
    Effects of food and alcohol on the pharmacokinetics of an oral, extended-release formulation of hydrocodone in healthy volunteers
    • 7
    • PDF
    Endogenous opiates and behavior: 2013
    • 40

    References

    SHOWING 1-10 OF 36 REFERENCES
    Excretion profile of hydrocodone, hydromorphone and norhydrocodone in urine following single dose administration of hydrocodone to healthy volunteers.
    • 15
    • Highly Influential
    • PDF
    Effect of cytochrome P450 2D1 inhibition on hydrocodone metabolism and its behavioral consequences in rats.
    • 39
    • PDF
    Inhibition of cytochrome P450 2D6 metabolism of hydrocodone to hydromorphone does not importantly affect abuse liability.
    • 76
    • PDF
    The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats.
    • 58
    • Highly Influential
    CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone
    • 165
    • Highly Influential
    Hydromorphone efficacy and treatment protocol impact on tolerance and mu-opioid receptor regulation.
    • 28
    Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer
    • 94
    Activation of G-Proteins by Morphine and Codeine Congeners: Insights to the Relevance of O- and N-Demethylated Metabolites at μ- and δ-Opioid Receptors
    • 82
    • Highly Influential
    • PDF
    CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes.
    • 107