In Vitro and in Vivo Evaluation of Native Glucagon and Glucagon Analog (MAR-D28) during Aging: Lack of Cytotoxicity and Preservation of Hyperglycemic Effect

@article{Ward2010InVA,
  title={In Vitro and in Vivo Evaluation of Native Glucagon and Glucagon Analog (MAR-D28) during Aging: Lack of Cytotoxicity and Preservation of Hyperglycemic Effect},
  author={W. Ward and R. Massoud and Cory Szybala and J. Engle and J. Youssef and J. Carroll and C. Roberts and R. DiMarchi},
  journal={Journal of Diabetes Science and Technology},
  year={2010},
  volume={4},
  pages={1311 - 1321}
}
  • W. Ward, R. Massoud, +5 authors R. DiMarchi
  • Published 2010
  • Chemistry, Medicine
  • Journal of Diabetes Science and Technology
  • Background: For automated prevention of hypoglycemia, there is a need for glucagon (or an analog) to be sufficiently stable so that it can be indwelled in a portable pump for at least 3 days. However, under some conditions, solutions of glucagon can form amyloid fibrils. Currently, the usage instructions for commercially available glucagon allow only for its immediate use. Methods: In NIH 3T3 fibroblasts, we tested amyloid formation and cytotoxicity of solutions of native glucagon and the… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    The diabetes technology group at Imperial College have developed a bio-inspired artificial pancreas (BiAP) system which uses a control algorithm based on a mathematical model of… Expand
    ConditionsType 1 Diabetes
    InterventionDevice

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 20 CITATIONS

    Biochemical stabilization of glucagon at alkaline pH.

    A Novel, Stable, Aqueous Glucagon Formulation Using Ferulic Acid as an Excipient

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 13 REFERENCES

    Amyloid-a state in many guises: survival of the fittest fibril fold.

    • J. Pedersen, D. Otzen
    • Chemistry, Medicine
    • Protein science : a publication of the Protein Society
    • 2008