In Vitro and In Vivo Studies of the Trypanocidal Effect of Novel Quinolines.


Therapies for human African trypanosomiasis and Chagas disease, caused by Trypanosoma brucei and Trypanosoma cruzi, respectively, are limited, providing minimal therapeutic options for the millions of individuals living in very poor communities. Here the effects of 10 novel quinolines are evaluated in silico and by phenotypic studies using in vitro and in… (More)
DOI: 10.1128/AAC.01936-17