In Vitro and In Vivo Properties of BAL30376, a β-Lactam and Dual β-Lactamase Inhibitor Combination with Enhanced Activity against Gram-Negative Bacilli That Express Multiple β-Lactamases

@article{Page2011InVA,
  title={In Vitro and In Vivo Properties of BAL30376, a $\beta$-Lactam and Dual $\beta$-Lactamase Inhibitor Combination with Enhanced Activity against Gram-Negative Bacilli That Express Multiple $\beta$-Lactamases},
  author={M. Page and Clothilde Dantier and E. Desarbre and B. Gaucher and K. Gebhardt and A. Schmitt-Hoffmann},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2011},
  volume={55},
  pages={1510 - 1519}
}
ABSTRACT BAL30376 is a triple combination comprising a siderophore monobactam, BAL19764; a novel bridged monobactam, BAL29880, which specifically inhibits class C β-lactamases; and clavulanic acid, which inhibits many class A and some class D β-lactamases. The MIC90 was ≤4 μg/ml (expressed as the concentration of BAL19764) for most species of the Enterobacteriaceae family, including strains that produced metallo-β-lactamases and were resistant to all of the other β-lactams tested. The MIC90 for… Expand
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