In Vitro and In Vivo Neurotoxicity of Prion Protein Oligomers

@article{Simoneau2007InVA,
  title={In Vitro and In Vivo Neurotoxicity of Prion Protein Oligomers},
  author={Steve Simoneau and Human Rezaei and Nicole Sal{\`e}s and Gunnar Kaiser-Schulz and Maxime Lefebvre-Roque and Catherine Vidal and Jean-Guy Fournier and Julien Comte and Franziska Wopfner and Jeanne Grosclaude and Hermann M Sch{\"a}tzl and Corinne Ida Lasm{\'e}zas},
  journal={PLoS Pathogens},
  year={2007},
  volume={3},
  pages={136 - 144}
}
The mechanisms underlying prion-linked neurodegeneration remain to be elucidated, despite several recent advances in this field. Herein, we show that soluble, low molecular weight oligomers of the full-length prion protein (PrP), which possess characteristics of PrP to PrPsc conversion intermediates such as partial protease resistance, are neurotoxic in vitro on primary cultures of neurons and in vivo after subcortical stereotaxic injection. Monomeric PrP was not toxic. Insoluble, fibrillar… CONTINUE READING

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