In Vitro and In Vivo Evaluations of PLGA Microspheres Containing Nalmefene


Poor patient compliance, untoward reactions and unstable blood drug levels after the bolus administration are impeding the pharmacotherapy for insobriety. A long-acting preparation may address these limitations. The aim of this paper was to further investigate the in vitro characteristics and in vivo performances of nalmefene microspheres. Nalmefene was… (More)
DOI: 10.1371/journal.pone.0125953


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