In Vitro and In Vivo Evaluations of PLGA Microspheres Containing Nalmefene

Abstract

Poor patient compliance, untoward reactions and unstable blood drug levels after the bolus administration are impeding the pharmacotherapy for insobriety. A long-acting preparation may address these limitations. The aim of this paper was to further investigate the in vitro characteristics and in vivo performances of nalmefene microspheres. Nalmefene was… (More)
DOI: 10.1371/journal.pone.0125953

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