In Vitro and In Vivo Evaluation of Casein as a Drug Carrier for Enzymatically Triggered Dissolution Enhancement from Solid Dispersions

@article{BaniJaber2016InVA,
  title={In Vitro and In Vivo Evaluation of Casein as a Drug Carrier for Enzymatically Triggered Dissolution Enhancement from Solid Dispersions},
  author={Ahmad Khaled Bani-Jaber and Iyad Daoud Alshawabkeh and Samaa Abdullah and Imad I. Hamdan and A R Kamali Ardakani and Maha Habash},
  journal={AAPS PharmSciTech},
  year={2016},
  volume={18},
  pages={1750-1759}
}
Due to its unique properties, such as biodegradability, biocompatibility, high amphiphilic property, and micelle formation, casein (CS) has been increasingly studied for drug delivery. We used CS as a drug carrier in solid dispersions (SDs) and evaluated the effect of its degradation by trypsin on drug dissolution from the dispersions. SDs of CS and mefenamic acid (MA) were prepared by physical mixing, kneading, and coprecipitation methods. In comparison to pure MA, the dispersions were… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 24 REFERENCES

Preparation and characterization of dipyridamole solid dispersions for stabilization of supersaturation: effect of precipitation inhibitors type and molecular weight

  • R Patadia, K Mittal, R Mashru, C. Vora
  • Pharm Dev Technol
  • 2015

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