In Vitro and In Vivo Anti-Inflammatory Activity of 17-O-Acetylacuminolide through the Inhibition of Cytokines, NF-κB Translocation and IKKβ Activity

@inproceedings{Achoui2010InVA,
  title={In Vitro and In Vivo Anti-Inflammatory Activity of 17-O-Acetylacuminolide through the Inhibition of Cytokines, NF-κB Translocation and IKKβ Activity},
  author={Mouna Achoui and D. R. Appleton and Mahmood Ameen Abdulla and Khalijah Binti Awang and Mustafa Ali Mohd and Mohd Rais Mustafa},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND AND PURPOSE 17-O-acetylacuminolide (AA), a diterpenoid labdane, was isolated for the first time from the plant species Neouvaria foetida. The anti-inflammatory effects of this compound were studied both in vitro and in vivo. EXPERIMENTAL APPROACH Plant extracts were initially tested against LPS-stimulated release of tumor necrosis factor alpha (TNF-α) from murine macrophages (RAW264.7 cells). Based on bioassay-guided fractionation, the active compound was identified as AA. AA was… CONTINUE READING