In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells.

@article{Soudais2015InVA,
  title={In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells.},
  author={Claire Soudais and Fatoumata Samassa and Manal Sarkis and Lionel le Bourhis and St{\'e}phanie Bessoles and Didier Blanot and Mireille Herv{\'e} and Fr{\'e}d{\'e}ric Schmidt and Dominique Mengin-Lecreulx and Olivier Lantz},
  journal={Journal of immunology},
  year={2015},
  volume={194 10},
  pages={4641-9}
}
Mucosal-associated invariant T (MAIT) cells recognize microbial compounds presented by the MHC-related 1 (MR1) protein. Although riboflavin precursor derivatives from Gram-positive bacteria have been characterized, some level of ligand heterogeneity has been suggested through the analysis of the MAIT cell TCR repertoire in humans and differential reactivity of human MAIT cell clones according to the bacteria. In this study, using Gram-negative bacteria mutated for the riboflavin biosynthetic… CONTINUE READING
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