In Vitro Susceptibilities of Clinical Isolates of Candida Species, Cryptococcus neoformans, and Aspergillus Species to Itraconazole: Global Survey of 9,359 Isolates Tested by Clinical and Laboratory Standards Institute Broth Microdilution Methods

@article{Pfaller2005InVS,
  title={In Vitro Susceptibilities of Clinical Isolates of Candida Species, Cryptococcus neoformans, and Aspergillus Species to Itraconazole: Global Survey of 9,359 Isolates Tested by Clinical and Laboratory Standards Institute Broth Microdilution Methods},
  author={Michael A. Pfaller and Linda D. Boyken and Richard J. Hollis and Shawn A. Messer and Shailesh Tendolkar and Daniel J. Diekema},
  journal={Journal of Clinical Microbiology},
  year={2005},
  volume={43},
  pages={3807 - 3810}
}
ABSTRACT The in vitro activity of itraconazole was determined against 7,299 isolates of Candida spp., 1,615 isolates of Cryptococcus neoformans, and 445 isolates of Aspergillus spp. obtained from over 200 medical centers worldwide. Itraconazole was active against all Candida spp. (96% of MICs were ≤1 μg/ml) with the exception of C. glabrata (77% of MICs were ≤1 μg/ml). Itraconazole inhibited 94% of C. krusei and 84% of other fluconazole-resistant Candida species, exclusive of C. glabrata, at a… Expand
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