In Vitro Study of a Medical Device to Enhance Arteriovenous Fistula Eligibility and Maturation.

Abstract

The arteriovenous fistula eligibility (AFE) system (Flow Forward Medical, Olathe, KS) is a small, temporary, wearable rotary blood pump system designed to rapidly dilate peripheral veins in hemodialysis patients and improve outcomes after arteriovenous fistula (AVF) creation. A benchtop pulsatile mock circulatory loop was developed to model forearm circulation and to compare the hemodynamics of the AFE system with those of a conventional radiocephalic AVF. The AFE system maintained a mean wall shear stress (mWSS) within the 2.5-7.5 Pa target range for cephalic outflow veins of 2-6 mm diameter, which when applied clinically will provide better control of mWSS during the outflow vein maturation process when compared with a conventional AVF. These results support further study to determine whether or not vein preconditioning with the AFE system under controlled levels of mWSS will promote improved AVF outcomes.

DOI: 10.1097/MAT.0000000000000240

Cite this paper

@article{Loree2015InVS, title={In Vitro Study of a Medical Device to Enhance Arteriovenous Fistula Eligibility and Maturation.}, author={Howard M Loree and George Agyapong and Elyse G Favreau and Gwendolyn A Ngai and Geoff D Tansley and Bradley S Dixon and F Nicholas Franano}, journal={ASAIO journal}, year={2015}, volume={61 4}, pages={480-6} }