In Vitro Study of Mutagenesis Induced by Crocidolite-Exposed Alveolar Macrophages NR8383 in Cocultured Big Blue Rat2 Embryonic Fibroblasts

Abstract

Asbestos-induced mutagenicity in the lung may involve reactive oxygen/nitrogen species (ROS/RNS) released by alveolar macrophages. With the aim of proposing an alternative in vitro mutagenesis test, a coculture system of rat alveolar macrophages (NR8383) and transgenic Big Blue Rat2 embryonic fibroblasts was developed and tested with a crocidolite sample… (More)
DOI: 10.1155/2010/323828

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@inproceedings{Guichard2010InVS, title={In Vitro Study of Mutagenesis Induced by Crocidolite-Exposed Alveolar Macrophages NR8383 in Cocultured Big Blue Rat2 Embryonic Fibroblasts}, author={Yves Guichard and Laurent Gat{\'e} and Christian Darn{\'e} and M Bottin and Cristina Langlais and J C Micillino and Mich{\`e}le Goutet and Schmit Julien and Binet St{\'e}phane}, booktitle={Journal of toxicology}, year={2010} }