In Vitro Studies of the Folding and Assembly Mechanism of Hemoglobin

@inproceedings{Samuel2017InVS,
  title={In Vitro Studies of the Folding and Assembly Mechanism of Hemoglobin},
  author={Premila P. Samuel and William C. Ou and George N. Phillips and John S Olson},
  year={2017}
}
Deriving the pathway for human hemoglobin assembly is important both for developing treatments for hemoglobinopathies and for designing robust acellular hemoglobin oxygen carriers. The adult human hemoglobin (HbA) comprises two globin heterodimers, (α1β1)(α2β2), with each subunit containing a heme group for coordination of oxygen and having a tertiary structure very similar to the monomeric paralog, myoglobin.In order to determine the complete folding mechanism, we have measured and analyzed… CONTINUE READING