• Corpus ID: 75702064

In Vitro Sensitivity of Plasmodium falciparum to Chloroquine in Dongfang City in Hainan Province

@article{Pei2003InVS,
  title={In Vitro Sensitivity of Plasmodium falciparum to Chloroquine in Dongfang City in Hainan Province},
  author={Chen Pei},
  journal={Journal of Tropical Medicine},
  year={2003}
}
  • Chen Pei
  • Published 2003
  • Medicine
  • Journal of Tropical Medicine
Objective To examine the sensitivity of Plasmodium falciparum to chloroquine. Methods WHO standard micro test and in vitro test were used. Results Survey in 1986~1987 and 1999~2001 showed that the chloroquine resistant rate of P. falciparum were 63 73% and 71 29% with the IC 50 of 1 08pmol/μl and 1 10pmol/μl respectively. The mean concentration for complete inhibition of schizont formation were 6 19pmol/μl and 5 57pmol/μl in 1986~1987 and 1999~2001 respectively. Conclusion The resistance to… 
1 Citations
Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of chloroquine use against P. falciparum malaria in Hainan, People's Republic of China.
TLDR
Low prevalence of the PfCRT 76T marker is consistent with greater rates of chloroquine sensitivity from in vitro drug assays of blood samples in 1997 and 2001, and monitoring for continued decreases will provide valuable information for future drug-use policies in China.