In Vitro Reactivation of Replication-Competent and Infectious HIV-1 by Histone Deacetylase Inhibitors

@inproceedings{Banga2016InVR,
  title={In Vitro Reactivation of Replication-Competent and Infectious HIV-1 by Histone Deacetylase Inhibitors},
  author={Riddhima Banga and Francesco Andrea Procopio and Matthias Cavassini and Matthieu Perreau and Guido Silvestri},
  booktitle={Journal of virology},
  year={2016}
}
UNLABELLED The existence of long-lived HIV-1-infected resting memory CD4 T cells is thought to be the primary obstacle to HIV-1 eradication. In the search for novel therapeutic approaches that may reverse HIV-1 latency, inhibitors of histone deacetylases (HDACis) have been tested to reactivate HIV-1 replication with the objective of rendering HIV-1-infected cells susceptible to elimination either by HIV-specific CD8 T cells or through virus-mediated cytopathicity. In the present study, we… CONTINUE READING
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