In Vitro RNase and Nucleic Acid Binding Activities Implicate Coilin in U snRNA Processing

@inproceedings{Broome2012InVR,
  title={In Vitro RNase and Nucleic Acid Binding Activities Implicate Coilin in U snRNA Processing},
  author={Hanna J. Broome and Michael D Hebert},
  booktitle={PloS one},
  year={2012}
}
Coilin is known as the marker protein for Cajal bodies (CBs), subnuclear domains important for the biogenesis of small nuclear ribonucleoproteins (snRNPs) which function in pre-mRNA splicing. CBs associate non-randomly with U1 and U2 gene loci, which produce the small nuclear RNA (snRNA) component of the respective snRNP. Despite recognition as the CB marker protein, coilin is primarily nucleoplasmic, and the function of this fraction is not fully characterized. Here we show that coilin binds… CONTINUE READING

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