In Vitro Permeability of Poorly Aqueous Soluble Compounds Using Different Solubilizers in the PAMPA Assay with Liquid Chromatography/Mass Spectrometry Detection

@article{Liu2003InVP,
  title={In Vitro Permeability of Poorly Aqueous Soluble Compounds Using Different Solubilizers in the PAMPA Assay with Liquid Chromatography/Mass Spectrometry Detection},
  author={Hanlan Liu and Chantel L Sabus and Guy T Carter and Chao Du and Alex Avdeef and Mark Tischler},
  journal={Pharmaceutical Research},
  year={2003},
  volume={20},
  pages={1820-1826}
}
Purpose. This study compares the use of UV-VIS detection with liquid chromatography/mass spectrometry (LC/MS) detection for the PAMPA (Parallel Artificial Membrane Permeability Assay) permeability determination of compounds in the drug discovery stage. LC/MS detection offers a selective and sensitive method for the determination of the PAMPA permeability for compounds that do not contain a UV chromophore or possess a low UV extinction coefficient. To enhance the reliability of our permeability… CONTINUE READING

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