In Vitro P450-Mediated Metabolism of Exemestane


Exemestane is a potent and irreversible steroidal aromatase inhibitor drug used for the treatment of estrogen receptor-positive breast cancer. Our aim was to identify and assess the contribution of the specific P450s responsible for exemestane primary in vitro metabolism. Using HPLC and LC-MS/MS analytical techniques, 17-hydroexemestane (MI) and 6… (More)


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