In Vitro Nail Penetration and Antifungal Activity of Tavaborole, a Boron-Based Pharmaceutical.

@article{Coronado2015InVN,
  title={In Vitro Nail Penetration and Antifungal Activity of Tavaborole, a Boron-Based Pharmaceutical.},
  author={Dina Coronado and Tejal Merchant and Sanjay Chanda and Lee Thomas Zane},
  journal={Journal of drugs in dermatology : JDD},
  year={2015},
  volume={14 6},
  pages={609-14}
}
An effective topical antifungal medication must penetrate through the nail plate at sufficient concentrations to eradicate the fungal infection. Tavaborole topical solution, 5% is a novel boron-based pharmaceutical approved for the treatment of toenail onychomycosis due to Trichophyton rubrum or T mentagrophytes. Four in vitro studies assessed the antifungal activity and nail penetration of tavaborole. In Study 1, tavaborole demonstrated minimum inhibitory concentration (MIC) values ranging… CONTINUE READING