In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties.

@article{Steven2020InVM,
  title={In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties.},
  author={J. Steven and Obinna C. Ubah and Magdalena J Buschhaus and Marina Kovaleva and L. Ferguson and A. Porter and C. Barelle},
  journal={Methods in molecular biology},
  year={2020},
  volume={2070},
  pages={
          115-142
        }
}
  • J. Steven, Obinna C. Ubah, +4 authors C. Barelle
  • Published 2020
  • Biology, Medicine
  • Methods in molecular biology
  • VNAR domains are the binding regions of new antigen receptor proteins (IgNAR) which are unique to sharks, skates, and rays (Elasmobranchii). Individual VNAR domains can bind antigens independently and are the smallest reported adaptive immune recognition entities in the vertebrate kingdom. Sharing limited sequence homology with human immunoglobulin domains, their development and use as biotherapeutic agents require that they be humanized to minimize their potential immunogenicity. Efforts to… CONTINUE READING
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