In Vitro Immunomodulatory Effects of Human Corneal Stromal Cells on Human Th17 Cells.

@article{Lee2015InVI,
  title={In Vitro Immunomodulatory Effects of Human Corneal Stromal Cells on Human Th17 Cells.},
  author={J. J. Lee and Jin Suk Ryu and Hyun Jeong Jeong and Mee Kum Kim and Won Ryang Wee},
  journal={Ocular immunology and inflammation},
  year={2015},
  volume={23 3},
  pages={194-204}
}
PURPOSE To investigate the immunomodulatory effects of human corneal stromal cells on the function of Th17 cells, in vitro. METHODS Th17 cells were co-cultured with corneal stromal cells with or without 1-methyltryptophan, 1400w dihydrochloride, interleukin (IL)-10 inhibitor, or transforming growth factor-beta (TGF-β) inhibitor. The secretion of IL-17A by Th17 cells and the upregulation of T regulatory (Treg) cell frequencies were evaluated. Transwell assays were conducted to evaluate whether… CONTINUE READING