In Vitro Epithelial Organoid Generation Induced by Substrate Nanotopography

Abstract

The extracellular matrix (ECM) exhibits tissue-specific topography and composition and plays a crucial role in initiating the biochemical and biomechanical signaling required for organizing cells into distinct tissues during development. How single cells assemble into structures featuring specific shapes in response to external cues is poorly understood. We… (More)
DOI: 10.1038/srep09293

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