In Vitro Effect of Homocysteine on Some Parameters of Oxidative Stress in Rat Hippocampus

@article{Streck2003InVE,
  title={In Vitro Effect of Homocysteine on Some Parameters of Oxidative Stress in Rat Hippocampus},
  author={Emilio Luiz Streck and Paula S. Vieira and Cl{\'o}vis Milton Duval Wannmacher and Carlos Severo Dutra-Filho and Moacir Wajner and Angela T. S. Wyse},
  journal={Metabolic Brain Disease},
  year={2003},
  volume={18},
  pages={147-154}
}
Homocystinuria is an inherited metabolic disease characterized biochemically by increased blood and brain levels of homocysteine caused by severe deficiency of cystathionine β-synthase activity. Affected patients present mental retardation, seizures, and atherosclerosis. Oxidative stress plays an important role in the pathogenesis of many neurodegenerative and vascular diseases, such Alzheimer's disease, stroke, and atherosclerosis. However, the mechanisms underlying the neurological damage… CONTINUE READING
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