In Vitro Effect of DFC-2 on Mycolic Acid Biosynthesis in Mycobacterium tuberculosis.

Abstract

DFC-2, a methyl 5-[2-(dimethylamino)ethoxy]-7,12-dioxo-7,12-dihydrodinaphtho[1,2-b:2',3'-d]furan-6-carboxylate, is reported to have antitubercular effects against Mycobacterium tuberculosis. At concentrations ranging from 0.19 to 0.39 μg/ml, DFC-2 inhibited both drug-susceptible and -resistant strains of M. tuberculosis. Microarray analyses were employed to… (More)
DOI: 10.4014/jmb.1705.05013

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Cite this paper

@article{Kim2017InVE, title={In Vitro Effect of DFC-2 on Mycolic Acid Biosynthesis in Mycobacterium tuberculosis.}, author={Sukyung Kim and Hoonhee Seo and Hafij Al Mahmud and Md Imtiazul Islam and Yong-Sik Kim and Jiwon Lyu and Kung-woo Nam and Byung-Eui Lee and Kee-In Lee and Ho-Yeon Song}, journal={Journal of microbiology and biotechnology}, year={2017}, volume={27 11}, pages={1932-1941} }