In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development

@article{Ubah2020InVE,
  title={In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development},
  author={Obinna C. Ubah and Andrew J. Porter and C. Barelle},
  journal={Journal of Immunology Research},
  year={2020},
  volume={2020}
}
  • Obinna C. Ubah, Andrew J. Porter, C. Barelle
  • Published 2020
  • Medicine
  • Journal of Immunology Research
  • Anti-drug antibodies (ADAs), specific for biotherapeutic drugs, are associated with reduced serum drug levels and compromised therapeutic response. The impact of ADA on the bioavailability and clinical efficacy of blockbuster anti-hTNF-α monoclonal antibodies is well recognised, especially for adalimumab and infliximab treatments, with the large and complex molecular architecture of classical immunoglobulin antibody drugs, in part, responsible for the immunogenicity seen in patients. The… CONTINUE READING

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