In Vitro Drug Absorption Models. II. Salicylate, Cefoxitin, α-Methyldopa and Theophylline Uptake in Cells and Rings: Correlation with In Vivo Bioavailability

@article{Porter1985InVD,
  title={In Vitro Drug Absorption Models. II. Salicylate, Cefoxitin, α-Methyldopa and Theophylline Uptake in Cells and Rings: Correlation with In Vivo Bioavailability},
  author={Patty A. Porter and Iwona Osiecka and Ronald T. Borchardt and Joseph A. Fix and Linda J Frost and Colin R. Gardner},
  journal={Pharmaceutical Research},
  year={1985},
  volume={2},
  pages={293-298}
}
Isolated mucosal cells and everted intestinal rings have been examined as potential in vitro models for intestinal drug absorption. The uptake of salicylate, cefoxitin, α-methyldopa and theophylline was characterized on the basis of time, concentration and temperature dependence and compared to in vivo drug absorption. Theophylline was well absorbed in all systems. Biochemical studies supported a passive transport mechanism, although a significant temperature dependence was observed. Salicylate… CONTINUE READING