In Vitro Drug Absorption Models. I. Brush Border Membrane Vesicles, Isolated Mucosal Cells and Everted Intestinal Rings: Characterization and Salicylate Accumulation

@article{Osiecka1985InVD,
  title={In Vitro Drug Absorption Models. I. Brush Border Membrane Vesicles, Isolated Mucosal Cells and Everted Intestinal Rings: Characterization and Salicylate Accumulation},
  author={Iwona Osiecka and Patty A. Porter and Ronald T. Borchardt and Joseph A. Fix and Colin R. Gardner},
  journal={Pharmaceutical Research},
  year={1985},
  volume={2},
  pages={284-293}
}
Brush border membrane vesicles, isolated mucosal cells and everted rings from rat intestine were compared for their suitability for drug uptake studies. Vesicles from brush border membranes were judged to be metabolically and morphologically functional on the basis of biochemical and microscopic criteria. With the use of a collagenase-vascular-perfusion method, populations of villus, mid villus and crypt cells were separated. An alternative approach that is based on an EDTA-dissociation… CONTINUE READING

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