In Vitro Comparative Effect of Carbetocin and Oxytocin in Pregnant Human Myometrium with and without Oxytocin Pretreatment

  title={In Vitro Comparative Effect of Carbetocin and Oxytocin in Pregnant Human Myometrium with and without Oxytocin Pretreatment},
  author={Naida M. Cole and Josē Carlos Almeida Carvalho and Magda Erik-Soussi and Nivetha Ramachandran and Mrinalini Balki},
Background:The purpose of this study was to compare in vitro contractile effects of oxytocin and carbetocin on human term pregnant myometrium with and without oxytocin pretreatment. Methods:This laboratory investigation was conducted on myometrial samples from women undergoing elective cesarean deliveries. The samples were dissected into four strips and suspended in individual organ bath chambers containing physiologic salt solution. After equilibration, they were pretreated with oxytocin 10−5… Expand
In vitro contractile effects of agents used in the clinical management of postpartum haemorrhage.
Findings support a clear role for oxytocin as the first line agent for treatment of postpartum haemorrhage and raise doubts about the potential clinical usefulness of misoprostol. Expand
Adverse Effects of Carbetocin versus Oxytocin in the Prevention of Postpartum Haemorrhage after Caesarean Section: A Randomized Controlled Trial
In planned CS, a possible clinical significant lower incidence of nausea after carbetocin was noted but this was not statistically significant and there were no differences regarding BP, heart rate, the need for vasopressor, and blood loss. Expand
What does basic science tell us about the use of uterotonics?
  • T. Drew, M. Balki
  • Medicine
  • Best practice & research. Clinical obstetrics & gynaecology
  • 2019
This review focuses on the main classes of uterotonic drugs and outlines their molecular and physiological basis of action, and discusses the mechanism of oxytocin desensitisation and how basic science has helped us understand this phenomenon. Expand
International consensus statement on the use of uterotonic agents during caesarean section
It is routine to give a uterotonic drug following delivery of the neonate during caesarean section. However, there is much heterogeneity in the relevant research, which has largely been performed inExpand
Recent findings Rational use of uterotonics for cesarean section has been well studied in the past decades. Oxytocin remained as a first line uterotonics for cesarean section. For continuousExpand
Pharmacologic Prevention and Treatment of Postpartum Hemorrhage
The purpose of this review is to synthetize the latest evidence on the pharmacological management of postpartum hemorrhage (PPH) and apply it to the clinical context. The incidence of PPH in theExpand
Effect of aqueous extract of mango kernel (Mangifera Indica) on basal activity of virgin rat uterine smooth muscle: role of muscarinic receptors
Background: Mango belongs to the Anacardiaceae and the extracts from its stems, leaves, fruit and kernel are reported to affect smooth muscle contractility. We studied the role of cholinergicExpand
The role of carbetocin in the prevention and management of postpartum haemorrhage.
This review examines the current evidence for the use of carbetocin as an alternative to oxytocin, as a first-line agent in the pharmacological management of the third stage of labour. Expand
The Inter-Rater Reliability and Agreement of a 0 to 10 Uterine Tone Score in Cesarean Delivery.
The 0-10 numeric rating scale for uterine tone demonstrated good to excellent inter- rater reliability with 1 and 2 raters, respectively, and good inter-rater agreement. Expand
Mechanisms of normal labour
The mechanisms of myometrial contractility at an organ, cellular and molecular level are summarized. Expand


Oxytocin Pretreatment Attenuates Oxytocin-induced Contractions in Human Myometrium In Vitro
Pretreatment with oxytocin decreases oxytoc in-induced myometrial contractions in a concentration and time-dependent manner, likely as a function of the oxytocIn receptor desensitization phenomenon. Expand
Oxytocin Pretreatment Decreases Oxytocin-induced Myometrial Contractions in Pregnant Rats in a Concentration-dependent But Not Time-dependent Manner
The inhibition of the oxytocin-induced contractile response of pregnant rat myometrium is observed as early as 1 hour of preexposure to oxytoc in and is dependent on the preexposed oxytocIn concentration and not on the duration of its exposure. Expand
Comparative efficacy of uterotonic agents: in vitro contractions in isolated myometrial strips of labouring and non-labouring women
Oxytocin induces superior myometrial contractions compared with ergonovine, PGF2α, and misoprostol; however, it is still superior to the other uterotonics. Expand
Loss of myometrial oxytocin receptors during oxytocin-induced and oxytocin-augmented labour.
The decrease in receptor binding and mRNA in women receiving oxytocin infusion indicates that homologous receptor desensitization occurs in vivo. Expand
Serum oxytocin concentrations in elective caesarean delivery: a randomized comparison of three infusion regimens.
Serum oxytocin measurements made using enzyme immunoassay in healthy pregnant women undergoing elective caesarean delivery showed that administration of 80 IU oxytoc in over 30 min resulted in higher serum oxytocIn levels after 5 and 30 min than the two other regimens. Expand
Carbetocin versus oxytocin in caesarean section with high risk of post-partum haemorrhage.
A single injection of carbetocin appears to be more effective than a continuous infusion of oxytocin to prevent the PPH, with a similar haemodynamic profile and minor antidiuretic effect. Expand
Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section.
Carbetocin, a new drug for the prevention of uterine atony, appears to be more effective than a continuous infusion of oxytocin and has a similar safety profile. Expand
Oxytocin-induced desensitization of the oxytocin receptor.
Oxytocin-induced desensitization of myocytes to oxytocin stimulation occurred over a clinically relevant time frame and continued responsiveness of the cells to prostaglandin F(2)(alpha) stimulation indicated that postreceptor signaling pathways were maintained, which indicates that the oxytoc in receptor likely is involved in the mechanism of myocyte desensItization to Oxytocin stimulating. Expand
Double-blind, randomized comparison of the effect of carbetocin and oxytocin on intraoperative blood loss and uterine tone of patients undergoing cesarean section.
A single 100 micrograms intravenous injection of carbetocin is as effective and more reliable than a standard continuous infusion of oxytocin in maintaining adequate uterine tone and preventing excessive intraoperative blood loss during cesarean section after delivery of the placenta. Expand
Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trial
Carbetocin makes possible to obtain, with a single IV injection, results equivalent to those of oxytocin on the maintenance of uterine tonicity and the limitation of blood losses, in the peri- and in the post-operative period, during a delivery by CS. Expand