In Vitro Characterization of Ephedrine-Related Stereoisomers at Biogenic Amine Transporters and the Receptorome Reveals Selective Actions as Norepinephrine Transporter Substrates

@article{Rothman2003InVC,
  title={In Vitro Characterization of Ephedrine-Related Stereoisomers at Biogenic Amine Transporters and the Receptorome Reveals Selective Actions as Norepinephrine Transporter Substrates},
  author={R. Rothman and Nga Vu and J. Partilla and B. Roth and S. J. Hufeisen and B. Compton-Toth and Jon Birkes and R. Young and R. Glennon},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2003},
  volume={307},
  pages={138 - 145}
}
  • R. Rothman, Nga Vu, +6 authors R. Glennon
  • Published 2003
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
    • Ephedrine is a long-studied stimulant available both as a prescription and over-the-counter medication, as well as an ingredient in widely marketed herbal preparations, and is also used as a precursor for the illicit synthesis of methamphetamine. Ephedrine is related to phenylpropanolamine, a decongestant removed from the market place due to concerns that its use increased the risk of hemorrhagic stroke. Standard pharmacology texts emphasize that ephedrine is both a direct and indirect… CONTINUE READING
    View on ASPET
    chemistry.mdma.ch
    157 Citations
    Highly Influential Citations
    7
    Background Citations
    54
    Methods Citations
    20
    Results Citations
    2

    Paper Mentions

    Interventional Clinical Trial
    Water and Sudafed in Autonomic Failure
    The specific aim of this study is to determine whether water ingestion potentiates the pressor response to pseudoephedrine in patients with primary disorders of autonomic failure… Expand
    ConditionsMultiple System Atrophy, Shy-Drager Syndrome
    InterventionDrug, Other
    Vanderbilt University Medical Center
    October 2014 - December 2019
    157 Citations
    Citation Type

    Citation Type

    Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV)
    • 139
    • PDF
    Binding of the amphetamine-like 1-phenyl-piperazine to monoamine transporters.
    • 24
    Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs.
    • 46
    • PDF
    Pharmacological Effects of Ephedrine Alkaloids on Human α1- and α2-Adrenergic Receptor Subtypes
    • 58
    • Highly Influenced
    Neuropharmacology of Synthetic Cathinones.
    • 9
    Cellular Uptake of Psychostimulants – Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?
    Using Ca2+-channel biosensors to profile amphetamines and cathinones at monoamine transporters: electro-engineering cells to detect potential new psychoactive substances
    • 2
    • Highly Influenced
    Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive ‘Bath Salts’ Products
    • 317
    • PDF
    The Designer Methcathinone Analogs, Mephedrone and Methylone, are Substrates for Monoamine Transporters in Brain Tissue
    • 343
    • PDF
    Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.
    • 18

    References

    SHOWING 1-10 OF 38 REFERENCES
    Direct effects of ephedrine isomers on human β-adrenergic receptor subtypes
    • 74
    Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes.
    • 39
    Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain.
    • 58
    • PDF
    The pharmacology of psychoactive alkaloids from ephedra and catha.
    • P. Kalix
    • Medicine
    • Journal of ethnopharmacology
    • 1991
    • 90
    3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
    • 257
    • PDF
    Discriminative Stimulus Properties of (−)Ephedrine
    • 30
    • PDF
    Behavioural effects of cathinone, an amine obtained from Catha edulis Forsk.: comparisons with amphetamine, norpseudoephedrine, apomorphine and nomifensine.
    • 91
    Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.
    • B. Roth, K. Baner, +5 authors R. Rothman
    • Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2002
    • 268
    Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist
    • B. Roth, K. Baner, +5 authors R. Rothman
    • Chemistry
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2002
    • 578
    • PDF
    Evidence for Possible Involvement of 5-HT2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications
    • 581
    • PDF