In Vitro Characterization of Ephedrine-Related Stereoisomers at Biogenic Amine Transporters and the Receptorome Reveals Selective Actions as Norepinephrine Transporter Substrates
@article{Rothman2003InVC, title={In Vitro Characterization of Ephedrine-Related Stereoisomers at Biogenic Amine Transporters and the Receptorome Reveals Selective Actions as Norepinephrine Transporter Substrates}, author={Richard B. Rothman and Nga Vu and John S. Partilla and Bryan L. Roth and Sandra J. Hufeisen and Beth A Compton-Toth and Jon Birkes and Richard Young and Richard A Glennon}, journal={Journal of Pharmacology and Experimental Therapeutics}, year={2003}, volume={307}, pages={138 - 145} }
Ephedrine is a long-studied stimulant available both as a prescription and over-the-counter medication, as well as an ingredient in widely marketed herbal preparations, and is also used as a precursor for the illicit synthesis of methamphetamine. Ephedrine is related to phenylpropanolamine, a decongestant removed from the market place due to concerns that its use increased the risk of hemorrhagic stroke. Standard pharmacology texts emphasize that ephedrine is both a direct and indirect…
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