In Vitro Characterization of Ephedrine-Related Stereoisomers at Biogenic Amine Transporters and the Receptorome Reveals Selective Actions as Norepinephrine Transporter Substrates
@article{Rothman2003InVC, title={In Vitro Characterization of Ephedrine-Related Stereoisomers at Biogenic Amine Transporters and the Receptorome Reveals Selective Actions as Norepinephrine Transporter Substrates}, author={R. Rothman and Nga Vu and J. Partilla and B. Roth and S. J. Hufeisen and B. Compton-Toth and Jon Birkes and R. Young and R. Glennon}, journal={Journal of Pharmacology and Experimental Therapeutics}, year={2003}, volume={307}, pages={138 - 145} }
Ephedrine is a long-studied stimulant available both as a prescription and over-the-counter medication, as well as an ingredient in widely marketed herbal preparations, and is also used as a precursor for the illicit synthesis of methamphetamine. Ephedrine is related to phenylpropanolamine, a decongestant removed from the market place due to concerns that its use increased the risk of hemorrhagic stroke. Standard pharmacology texts emphasize that ephedrine is both a direct and indirect… CONTINUE READING
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References
SHOWING 1-10 OF 38 REFERENCES
Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes.
- Medicine
- Biochemical pharmacology
- 1999
- 39
Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain.
- Chemistry, Medicine
- European journal of pharmacology
- 2002
- 58
- PDF
The pharmacology of psychoactive alkaloids from ephedra and catha.
- Medicine
- Journal of ethnopharmacology
- 1991
- 90
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
- Medicine
- Molecular pharmacology
- 2003
- 257
- PDF
Discriminative Stimulus Properties of (−)Ephedrine
- Chemistry, Medicine
- Pharmacology Biochemistry and Behavior
- 1998
- 30
- PDF
Behavioural effects of cathinone, an amine obtained from Catha edulis Forsk.: comparisons with amphetamine, norpseudoephedrine, apomorphine and nomifensine.
- Chemistry, Medicine
- Bulletin on narcotics
- 1980
- 91
Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.
- Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2002
- 268
Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist
- Chemistry
- Proceedings of the National Academy of Sciences of the United States of America
- 2002
- 578
- PDF