In Vitro Biologic Activities of the Antimicrobials Triclocarban, Its Analogs, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens

@article{Ahn2008InVB,
  title={In Vitro Biologic Activities of the Antimicrobials Triclocarban, Its Analogs, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens},
  author={Ki Chang Ahn and Bin Zhao and Jiangang Chen and Gennady Cherednichenko and Enio Sanmarti and Michael S. Denison and Bill L. Lasley and Isaac N Pessah and Dietmar K{\"u}ltz and Dan Chang and Shirley J. Gee and Bruce D. Hammock},
  journal={Environmental Health Perspectives},
  year={2008},
  volume={116},
  pages={1203 - 1210}
}
Background Concerns have been raised about the biological and toxicologic effects of the antimicrobials triclocarban (TCC) and triclosan (TCS) in personal care products. Few studies have evaluated their biological activities in mammalian cells to assess their potential for adverse effects. Objectives In this study, we assessed the activity of TCC, its analogs, and TCS in in vitro nuclear-receptor–responsive and calcium signaling bioassays. Materials and methods We determined the biological… Expand
The in Vitro estrogenic activities of triclosan and triclocarban
TLDR
Results showed that TCS and TCC exerted estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF‐7 cells, and up‐regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCFs. Expand
Critical analysis of endocrine disruptive activity of triclosan and its relevance to human exposure through the use of personal care products
  • R. Witorsch
  • Biology, Medicine
  • Critical reviews in toxicology
  • 2014
TLDR
In vitro, in vivo, and epidemiologic studies reviewed herein show little evidence that TCS adversely affects gestation or postpartum development of offspring, and previously reported toxicity testing in a variety of mammalian species shows little evidence. Expand
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Triclocarban Mediates Induction of Xenobiotic Metabolism through Activation of the Constitutive Androstane Receptor and the Estrogen Receptor Alpha
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Effects of triclocarban on the transcription of estrogen, androgen and aryl hydrocarbon receptor responsive genes in human breast cancer cells.
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Triclosan Lacks (Anti-)Estrogenic Effects in Zebrafish Cells but Modulates Estrogen Response in Zebrafish Embryos
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Dose-Dependent Effects of Triclocarbon Exposure on Lipid Homeostasis in Rats.
TLDR
Although TCC exhibited dose-dependent toxicity, oral exposure with relative low dose TCC caused more significant hepatic lipogenesis of rats than realtive high and moderate doses of TCC used in this study, providing new insights into health effects of T CC exposure with different dosages in vivo. Expand
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