In Vitro Antimalarial Activity of Nucleic Acid Precursor Analogues in the Simian Malaria Plasmodium knowlesi1

@article{McCormick1974InVA,
  title={In Vitro Antimalarial Activity of Nucleic Acid Precursor Analogues in the Simian Malaria Plasmodium knowlesi1},
  author={G. J. McCormick and C. Canfield and G. Willet},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1974},
  volume={6},
  pages={16 - 21}
}
Analogues of nucleic acid precursors were screened for antimalarial activity in Plasmodium knowlesi by using an in vitro culture system. Activity was assessed by the degree of inhibition of incorporation of l-[methyl-14C]methionine into protein and of [8-14C]adenosine and [6-14C]orotic acid into ribonucleic acid and deoxyribonucleic acid. The incorporation of adenosine or orotic acid was effectively inhibited by many of the compounds, including 3′ analogues of purine nucleosides, many of the 6… Expand
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