In Vitro Adsorption and in Vivo Pharmacokinetic Interaction between Doxycycline and Frequently Used Mycotoxin Binders in Broiler Chickens.

@article{Mil2015InVA,
  title={In Vitro Adsorption and in Vivo Pharmacokinetic Interaction between Doxycycline and Frequently Used Mycotoxin Binders in Broiler Chickens.},
  author={Thomas De Mil and Mathias Devreese and Nathan Broekaert and Sophie Fraeyman and Patrick de Backer and Siska Croubels},
  journal={Journal of agricultural and food chemistry},
  year={2015},
  volume={63 17},
  pages={4370-5}
}
Mycotoxin binders are readily mixed in feeds to prevent uptake of mycotoxins by the animal. Concerns were raised for nonspecific binding with orally administered veterinary drugs by the European Food Safety Authority in 2010. This paper describes the screening for in vitro adsorption of doxycycline-a broad-spectrum tetracycline antibiotic-to six different binders that were able to bind >75% of the doxycycline. Next, an in vivo pharmacokinetic interaction study of doxycycline with two of the… CONTINUE READING