In Vitro Activity of St. John's Wort Against Cytochrome P450 Isozymes and P-Glycoprotein

  title={In Vitro Activity of St. John's Wort Against Cytochrome P450 Isozymes and P-Glycoprotein},
  author={B. Foster and E. Sockovie and S. Vandenhoek and N. Bellefeuille and Cathy E. Drouin and A. Krantis and J. Budzinski and J. Livesey and J. Arnason},
  journal={Pharmaceutical Biology},
  pages={159 - 169}
  • B. Foster, E. Sockovie, +6 authors J. Arnason
  • Published 2004
  • Chemistry
  • Pharmaceutical Biology
  • The inhibitory activity of 18 commercial St. John's wort products (Hypericum perforatum L. Hypericaceae) against human cytochrome P450 enzymes was assessed because recent studies have found that this herb can markedly affect disposition of concurrently used conventional drugs. For the most part, these studies have employed ethanolic extracts. However, many of the two dozen reported constituents or groups of compounds having pharmacological effects in Hypericum extracts have widely differing… CONTINUE READING
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