In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma.

@article{Greco2018InVA,
  title={In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma.},
  author={Ines Greco and Bernard D Hummel and Jaspreet Vasir and Jeffrey L. Watts and Jason D Koch and Johannes Hansen and Hanne M\orck Nielsen and Peter Damborg and Paul Robert Hansen},
  journal={Molecules},
  year={2018},
  volume={23 3}
}
Antimicrobial peptides (AMPs) hold promise as the next generation of antimicrobial agents, but often suffer from rapid degradation in vivo. Modifying AMPs with non-proteinogenic residues such as peptoids (oligomers of N-alkylglycines) provides the potential to improve stability. We have identified two novel peptoid-based compounds, B1 and D2, which are effective against the canine skin pathogen Staphylococcus pseudintermedius, the main cause of antibiotic use in companion animals. We report on… CONTINUE READING