In Vitro – In Vivo Correlation : Importance of Dissolution in IVIVC

  title={In Vitro – In Vivo Correlation : Importance of Dissolution in IVIVC},
  author={J-M. Cardot and Erick Beyssac and Monique Alric},
Introduction Correlations between in vitro and in vivo data (IVIVC) are often used during pharmaceutical development in order to reduce development time and optimize the formulation. A good correlation is a tool for predicting in vivo results based on in vitro data. IVIVC allows dosage form optimization with the fewest possible trials in man,fixes dissolution acceptance criteria,and can be used as a surrogate for further bioequivalence studies; it is also recommended by regulatory authorities… CONTINUE READING
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Beyssac,E. In vitro/in vivo correlations:Scientific implications and standardization. Eur.J.Drug Metab.and Pharmacokinet

  • Cardot. J-M
  • 1993
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