In Vitro–In Vivo Correlation on Delivery of Drug Candidates to Articular Cartilage

Abstract

In the treatment of osteoarthritis (OA), some of the therapeutic approaches require delivery of drug(s) to the diseased cartilage. Presence of adequate drug levels in the cartilage is one of the important criteria in selection and ranking of lead compounds. The purpose of this study was to investigate the correlation in cartilage compound levels between in… (More)
DOI: 10.1007/s11095-008-9557-8

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Cite this paper

@article{Wang2008InVV, title={In Vitro–In Vivo Correlation on Delivery of Drug Candidates to Articular Cartilage}, author={Qin Wang and Sonya S Glasson and Uma Raut and J J Emerson and Tracey Blanchet and Gary W. Bridson and Richard Sheldon and Nevena N Mollova and E Matthew Morris and Xin Xu and Vikram Patel}, journal={Pharmaceutical Research}, year={2008}, volume={25}, pages={1641-1646} }