In Vitro/in Vivo Correlation of Transdermal Naltrexone Prodrugs in Hairless Guinea Pigs

@article{Valiveti2005InVV,
  title={In Vitro/in Vivo Correlation of Transdermal Naltrexone Prodrugs in Hairless Guinea Pigs},
  author={Satyanarayana Valiveti and Kalpana S. Paudel and Dana C. Hammell and Mohamed O. Hamad and Jianhong Chen and Peter A. Crooks and Audra L Stinchcomb},
  journal={Pharmaceutical Research},
  year={2005},
  volume={22},
  pages={981-989}
}
The purpose of this investigation was to evaluate the in vitro and in vivo percutaneous absorption of the following prodrugs of naltrexone (NTX): 2′-ethylbutyryl-3-O-ester-NTX (ETBUT-ester), methyl-3-O-carbonate-NTX (ME-carbonate), ethyl-3-O-carbamate-NTX (ET-carbamate), and N,N-dimethyl-3-O-carbamate-NTX (DME-carbamate) in hairless guinea pigs. In vitro fluxes of NTX and its prodrugs through guinea pig skin were determined using a flow-through diffusion cell system. The pharmacokinetics of NTX… CONTINUE READING

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