In Vino Veritas: A Tale of Two Sirt1s?


Resveratrol increases life span in lower organisms by activating the NAD(+)-dependent histone deacetylase Sirt1. Studies by and now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1alpha. 
DOI: 10.1016/j.cell.2006.11.034


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@article{Koo2006InVV, title={In Vino Veritas: A Tale of Two Sirt1s?}, author={Seung-Hoi Koo and Marc R. Montminy}, journal={Cell}, year={2006}, volume={127}, pages={1091-1093} }