In Utero Exposure to Diethylhexyl Phthalate Affects Rat Brain Development: A Behavioral and Genomic Approach.

@article{Lin2015InUE,
  title={In Utero Exposure to Diethylhexyl Phthalate Affects Rat Brain Development: A Behavioral and Genomic Approach.},
  author={Han Lin and Kaiming Yuan and Linyan Li and Shiwen Liu and Senlin Li and Guoxin Hu and Qingquan Lian and Ren-Shan Ge},
  journal={International journal of environmental research and public health},
  year={2015},
  volume={12 11},
  pages={13696-710}
}
Diethylhexyl phthalate (DEHP) is one of the most widely utilized phthalate plasticizers. Previous studies have demonstrated that gestational or postnatal DEHP exposure induced adverse effects on rat brain development and function. In this study, we investigated the effects of gestational DEHP exposure on gene expression profiling in neonatal rat brain and cognitive function change at adulthood. Adult Sprague Dawley dams were orally treated with 10 or 750 mg/kg DEHP from gestational day 12 to 21… CONTINUE READING

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