In Situ Imidazole Activation of Ribonucleotides for Abiotic RNA Oligomerization Reactions

Abstract

The hypothesis that RNA played a significant role in the origin of life requires effective and efficient abiotic pathways to produce RNA oligomers. The most successful abiotic oligomerization reactions to date have utilized high-energy, modified, or pre-activated ribonucleotides to generate strands of RNA up to 50-mers in length. In spite of their success… (More)
DOI: 10.1007/s11084-015-9412-y

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