In Situ Hybridization and Reverse Transcription–Polymerase Chain Reaction for Cyclin D1 mRNA in the Diagnosis of Mantle Cell Lymphoma in Paraffin-Embedded Tissues

@article{Athanasiou2001InSH,
  title={In Situ Hybridization and Reverse Transcription–Polymerase Chain Reaction for Cyclin D1 mRNA in the Diagnosis of Mantle Cell Lymphoma in Paraffin-Embedded Tissues},
  author={Evangelia Athanasiou and Vassiliki A Kotoula and Prodromos Hytiroglou and Sophia Kouidou and Vassiliki D Kaloutsi and Constantine S. Papadimitriou},
  journal={Modern Pathology},
  year={2001},
  volume={14},
  pages={62-71}
}
Mantle cell lymphoma (MCL) is characterized by the chromosomal translocation t(11;14), which involves rearrangement of the bcl-1 proto-oncogene to the immunoglobulin heavy chain gene and results in overexpression of cyclin D1 mRNA. In this study, we evaluated the diagnostic relevance of three methods that may be helpful in the diagnosis of MCL: in situ… CONTINUE READING