In Situ Derivatization of (RS)-Mexiletine and Enantioseparation Using Micellar Liquid Chromatography: A Green Approach

@article{Alwera2018InSD,
  title={In Situ Derivatization of (RS)-Mexiletine and Enantioseparation Using Micellar Liquid Chromatography: A Green Approach},
  author={Shiv Alwera},
  journal={ACS Sustainable Chemistry & Engineering},
  year={2018},
  volume={6},
  pages={11653-11661}
}
  • Shiv Alwera
  • Published 2018
  • Chemistry
  • ACS Sustainable Chemistry & Engineering
  • Developing surfactant-based aqueous solvents as alternatives to organic solvents for chromatographic enantioseparation is highly desired. Surfactants are inexpensive, nontoxic, environmental friendly, and increase the solubility of organic compounds in aqueous solutions. In this work, the impact of surfactant-based aqueous solvents on RP-HPLC enantioseparation of (RS)-mexiletine is studied. The in situ derivatization of (RS)-mexiletine with chirally pure moieties [(S)-levofloxacin, (S… CONTINUE READING
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