In Situ Blood–Brain Barrier Transport of Nanoparticles

  title={In Situ Blood–Brain Barrier Transport of Nanoparticles},
  author={Joanna M. Koziara and Paul R. Lockman and David D. Allen and Russell J. Mumper},
  journal={Pharmaceutical Research},
Purpose. Two novel types of nanoparticles were evaluated as potential carriers for drugs across the blood–brain barrier (BBB). Methods. Nanoparticles were composed of biocompatible materials including emulsifying wax (E. Wax) or Brij 72. Brij 78 and Tween 80 were used as surfactants for E.Wax nanoparticles (E78 NPs) and Brij 72 nanoparticles (E72 NPs), respectively. Both nanoparticle formulations were prepared from warm microemulsion precursors using melted E. Wax or Brij 72 as the oil phase… CONTINUE READING

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