Corpus ID: 212497180

In Silico evaluation of alpha glucosidase and alpha amylase inhibitory activity of chemical constituents from Psoralea corylifolia

@inproceedings{Mounika2015InSE,
  title={In Silico evaluation of alpha glucosidase and alpha amylase inhibitory activity of chemical constituents from Psoralea corylifolia},
  author={L. Mounika},
  year={2015}
}
The current study is about the evaluation of chemical constituents of Psoralea corylifolia for the inhibitory activity of alpha glucosidase and alpha amylase. In this perspective, 46 constituents of Psoralea corylifolia were selected. Acarbose, a known alpha glucosidase and alpha amylase inhibitor, was used as standard. For alpha glucosidase, docking results showed that all the selected constituents of Psoralea corylifolia had binding energy ranging between -190.438 Kcal/mol to -98.969 Kcal/mol… Expand

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References

SHOWING 1-10 OF 24 REFERENCES
Antioxidants from a Chinese medicinal herb--Psoralea corylifolia L
Abstract The powder and extracts of Psoralea corylifolia L. were tested in lard at 100 °C by using the oxidative stability instrument (OSI) and were found to have strong antioxidant effects. SixExpand
Phytochemical Analysis and Antibacterial Efficacy of Babchi Oil (Psoralea corylifolia) Against Multi-drug Resistant Clinical Isolates
TLDR
This is the first report that documents the antibacterial efficacy of tannins found in babchi oil against MDR bacteria from clinical isolates and as a base for the development of novel potent drugs and phytomedicine. Expand
Antioxidative components of Psoralea corylifolia (Leguminosae)
TLDR
Bakuchiol (1) was the most potent antioxidant in microsomes and the inhibition of oxygen consumption induced by lipid peroxidation was time‐dependent, and protected human red blood cells against oxidative haemolysis. Expand
Antidermatophytic activity of extracts from Psoralea corylifolia (Fabaceae) correlated with the presence of a flavonoid compound.
Extracts obtained from seeds of Psoralea corylifolia showed several degrees of antifungal activity against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum and MicrosporumExpand
Studies on the chemical constituents of Psoralea corylifolia L.
A new isoflavone, corylinin (1), along with six known compounds, isopsoralen (2), psoralen (3), sophoracoumestan A (4), neobavaisoflavone (5), daidzin (6) and uracil (7), have been isolated from theExpand
Psoralea corylifolia L. (Buguchi) - folklore to modern evidence: review.
TLDR
An effort to give a detailed survey of the literature on its botany, phytochemistry and ethnopharmacology along with special emphasis given on pharmacological activities of plant P. corylifolia. Expand
Two New Benzofuran Derivatives, Corylifonol and Isocorylifonol from the Seeds of Psoralea corylifolia
The seeds of Psolalea corylifolia were extracted with ether and 60% EtOH, successively. The latter extract was found to contain the known constituents psoralen, angelicin, corylifolinin, bukuchiol,Expand
Preparative isolation and purification of psoralen and isopsoralen from Psoralea corylifolia by high-speed counter-current chromatography.
TLDR
Psoralen and isopsoralen were separated from Psoralea corylifolia by high-speed counter-current chromatography using a two-phase solvent system and identified with 1H NMR and 13C NMR. Expand
Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia
Abstract Two novel dimeric meroterpenoids, bisbakuchiols A and B, along with ( S )-bakuchiol were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). Bisbakuchiols A and B contain anExpand
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