In Silico Modeling of Immunotherapy and Stroma-Targeting Therapies in Human Colorectal Cancer.

@article{Kather2017InSM,
  title={In Silico Modeling of Immunotherapy and Stroma-Targeting Therapies in Human Colorectal Cancer.},
  author={Jakob Nikolas Kather and Jan Poleszczuk and Meggy Suarez-Carmona and Johannes Krisam and Pornpimol Charoentong and Nektarios A Valous and Cleo-Aron Weis and Luca Tavernar and Florian Leiss and Esther Herpel and Fee Klupp and Alexis B. Ulrich and Martin L Schneider and Alexander Marx and Dirk Jaeger and Niels Halama},
  journal={Cancer research},
  year={2017},
  volume={77 22},
  pages={6442-6452}
}
Despite the fact that the local immunological microenvironment shapes the prognosis of colorectal cancer, immunotherapy has shown no benefit for the vast majority of colorectal cancer patients. A better understanding of the complex immunological interplay within the microenvironment is required. In this study, we utilized wet lab migration experiments and quantitative histological data of human colorectal cancer tissue samples (n = 20) including tumor cells, lymphocytes, stroma, and necrosis to… CONTINUE READING
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