In Silico Investigations of Silk Fibroin Peptides Highlight their Therapeutic Values towards Wound Healing

This work validates an in vitro observation that silk peptides derived from the α-chymotrypsin digestion of fibroin heavy chain promote wound healing properties. A molecular level evidence of binding of these peptide fragments to growth factors, their receptors and the corresponding ligand-receptor complexes has been provided. The strengths of interactions… (More)