In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes

  title={In Silico Approaches to Identify Polyphenol Compounds as $\alpha$-Glucosidase and $\alpha$-Amylase Inhibitors against Type-II Diabetes},
  author={Jirawat Riyaphan and Dinh-Chuong Pham and Max K. Leong and Ching-Feng Weng},
Type-II diabetes mellitus (T2DM) results from a combination of genetic and lifestyle factors, and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α-amylase enzymes inhibitors can suppress peaks of postprandial glucose with surplus adverse effects, leading to efforts devoted to urgently seeking new anti-diabetes drugs from natural sources for delayed starch digestion. This review attempts to explore 10 families e.g., Bignoniaceae, Ericaceae, Dryopteridaceae… 

Tables from this paper

Insilico screening and pharmacokinetic properties of phytoconstituents from Ferula asafoetida H.Karst. (Heeng) as potential inhibitors of α-amylase and α-glucosidase for Type 2 Diabetes Mellitus

  • Gurpreet Singh
  • Biology, Chemistry
    Journal of Diabetes & Metabolic Disorders
  • 2022
Phytochemicals of F. asafoetida have the potential antidi diabetic properties which could be further used to develop into effective antidiabetic drug from a natural resource.

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

This review compiles current investigations into the role of polyphenols/flavonoids in the alleviation of cigarette smoke-induced inflammasome and provides a promising hit for rectifying the treatment of COPD.

Lignin-Mediated Silver Nanoparticle Synthesis for Photocatalytic Degradation of Reactive Yellow 4G and In Vitro Assessment of Antioxidant, Antidiabetic, and Antibacterial Activities

This study explored the potential of abundantly available sodium lignosulfonate (LS) as a reducer and fabricating agent in preparing silver nanoparticles (LS–Ag NPs). The operational conditions were



Natural Products as α-Amylase and α-Glucosidase Inhibitors and their Hypoglycaemic Potential in the Treatment of Diabetes: An Update

Recent data on plant extracts and isolated natural compounds that are being tested for their hypglycaemic activity are reviewed, ongoing research is highlighted, and the future persepctives are considered.

Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update.

Recent data on plant extracts and isolated natural compounds that are being tested for their hypglycaemic activity are reviewed, ongoing research is highlighted, and the future persepctives are considered.

Hypoglycemic Efficacy of Docking Selected Natural Compounds against α-Glucosidase and α-Amylase

In vitro and in vivo experiments suggest that selected natural compounds via molecular docking were confirmed as potential candidates of α-glucosidase and α-amylase inhibitors for treating diabetes.

Inhibition of α-glucosidase and α-amylase by flavonoid glycosides from Lu'an GuaPian tea: molecular docking and interaction mechanism.

New insight is provided into the potential application of Lu'an GuaPian green tea as a functional food ingredient to regulate postprandial hyperglycemia through inhibition of α-glucosidase/α-amylase by FGs, particularly the mono- and di- glycosides of kaempferol.

Inhibitory activity of α-amylase and α-glucosidase by plant extracts from the Brazilian cerrado.

The results suggest that the activity of these cerrado plants on α-amylase and α-glucosidase represents a potential tool for development of new strategies for treatment of diabetes.

In vitro and in vivo α-amylase and α-glucosidase inhibiting activities of the protein extracts from two varieties of bitter gourd (Momordica charantia L.)

Protein extracts from the fruits of the two varieties of bitter gourd inhibited α-amylase and α-glucosidase in vitro and lowered the blood glucose level in vivo on par with Acarbose when orally administrated to Streptozotocin-induced diabetic rats.

α-glucosidase inhibitors from plants: A natural approach to treat diabetes

The present review focuses on constituents isolated from different plants having α-glucosidase inhibitory potency along with IC50 values, which can retard the liberation of d-Glucose from dietary complex carbohydrates and delay glucose absorption, resulting in reduced postprandial plasma glucose levels and suppression of postpr andial hyperglycemia.

Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase

Despite some encouraging results, more research is required for developing a valuable anti-diabetic therapy using pancreatic alpha-amylase inhibitors of plant origin, and bioactive compounds of phenolic nature that exhibit anti-Amylase activity are presented.